John Robertson, CEO

(540) 239-0169
RobertsonJ@Rametrixtech.com

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COVID19

  • Infection with SARS-CoV-2 and development of COVID-19 disease is associated with a deleterious effect in renal function and structure.
  • This would be expected to potentially alter the molecular composition of urine.
  • Since COVID-19 evolved in 2019, there have been numerous reports of acute kidney injury (AKI) associated with this infection 1,2,3,4,5,6,7,8.
  • The incidence of AKI in COVID-19 patients has been estimated to range from about 27-50+% 9,10.
  • Early in the pandemic, several groups noted a correlation of disease severity, hospitalization, and intensive care admissions with increased risk for developing AKI 11, 12.
  • The contribution of cardiopulmonary dysfunction, renal hypoperfusion, and/or multidrug therapy leading to the development AKI has been well-known for decades prior to COVID-19 13. However, the role of renal viral infection in the development of AKI was uncertain.
  • Our ongoing studies, with colleagues at Carilion Clinic in Roanoke, VA, are focused on using our Rametrix® Technology, Inc. technology to predict the severity of COVID19 infection when patients are hospitalized and to see if our technology can predict the development of Long COVID19.

References

  1. Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, et al. COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group: Acute kidney injury in COVID-19: Emerging evidence of a distinct pathophysiology. J Am Soc Nephrol 2020; 31: 1380–1383
  2. Chen YT, Shao SC, Lai EC, Hung MJ, Chen YC. Mortality rate of acute kidney injury in SARS, MERS, and COVID‑19 infection: A systematic review and meta‑analysis. Crit Care 2020; 24: 439
  3. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 2020; 97: 829–838
  4. Ng JH, Bijol V, Sparks MA, Sise ME, Izzedine H, Jhaveri KD: Pathophysiology and pathology of acute kidney injury in patients with COVID-19. Adv Chronic Kidney Dis 2020; 27: 365–376
  5. Pei G, Zhang Z, Peng J, Liu L, Zhang C, Yu C, et al. Renal involvement and early prognosis in patients with COVID-19 pneumonia. J Am Soc Nephrol 2020; 31: 1157–1165, 2020
  6. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020; 323: 2052–2059
  1. Sharma P, Uppal NN, Wanchoo R, Shah HH, Yang Y, Parikh R, et al. COVID-19–associated kidney injury: A case series of kidney biopsy findings. J Am Soc Nephrol 2020; 31: 1948–1958
  2. Su H, Yang M, Wan C, Yi L-X, Tang F, Zhu H-Y, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 2020; 98: 219–227, 2020
  3. Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, Barnett RL, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int 2020; 98: 209–218, 2020
  4. Mohamed MM, Lukitsch I, Torres-Ortiz AE, Walker JB, Varghese V, Hernandez-Arroyo CF. Acute kidney injury associated with coronavirus disease 2019 in urban New Orleans. Kidney360 2020; 1: 614–622
  5. Fisher M, Neugarten J, Bellin E, Yunes M, Stahl L, Johns TS, et al. AKI in hospitalized patients with and without COVID-19: A comparison study. J Am Soc Nephrol 2020; 31: 2145–2157
  1. Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, et al. The association of COVID-19 with acute kidney injury independent of severity of illness: A multicenter cohort study. Am J Kidney Dis 2021; 77: 490–499.e1
  2. Murugan R, Kellum JA: Acute kidney injury: what’s the prognosis? Nat Rev Nephrol. 2011; 7(4):209-217